613 Evaluating the role of copper ions in the various phases of burn and wound healing by using an ex vivo human burn model

Copper is known for its strong biocidal and anti-inflammatory properties, as an accelerator of angiogenesis, cell proliferation secretion Extra Cellular Matrix (ECM) proteins. It therefore excellent candidate in the treatment wounds. The role few factors which presumably mediate copper’s ability to promote wound healing processes already established. However, molecular mechanism by copper facilitates healthy a way that can explain connection between early events microenvironment with later such tissue formation remodeling not entirely clear. induce was examined ex vivo model burned human skin. Gene expression protein during first days following burn infliction, were tested qPCR ELISA, respectively. Proliferation, migration apoptosis keratinocytes fibroblasts vitro. ions found re-epithelization moderate inflammatory response thermal injury vivo. In vitro experiments demonstrated accelerated keratinocytes, but fibroblasts, administration. Though induces ECM proteins skin, it lowers TGFβ1 from injured skin tissue. Inhibition response, lowering amounts lack effect on fibroblast migration, combine results clinical trials showing impregnated dressing wounds reduces swelling scar surgical wounds, may indicate contribution reduction severity formation.